Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronavirusesArticle Published on 2022-11-052022-11-15 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] Analysis common cold Coronaviruses Compound COVID-19 COVID-19 therapeutics cytotoxicity effective gene expression profile globe Heat shock homoharringtonine host cell response host response in silico in vitro modulating other coronavirus pandemic pathway Prevent provided reported SARS-CoV-2 SARS-CoV-2 biology screened severe symptoms tanespimycin target tested unique Vaccine viral infection [DOI] 10.1038/s41598-022-21984-w PMC 바로가기
Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemicArticle Published on 2022-09-142022-11-15 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] antibody Antibody titers Antigen CD4 CD4+ T cell common cold common cold coronavirus common cold Coronaviruses comparable coronavirus Endemic Frequency immune immune memory immune response infection prevalence influence longitudinal analysis magnitude memory outcome pandemic performed RBD-specific IgG response reactivity repeated response responses SARS-CoV-2 SARS-CoV-2 immunity SARS-COV-2 infection Steady state steady state. sustained T cells Vaccine development [DOI] 10.1016/j.chom.2022.07.012 PMC 바로가기
Contribution of Coronavirus-Specific Immunoglobulin G Responses to Complement Overactivation in Patients with Severe Coronavirus Disease 2019Article Published on 2022-09-132022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] Activation acute respiratory syndrome addition analysis and antibodies antibody C1q circulating classical classical pathway common cold common cold coronavirus common cold Coronaviruses complement complement system. coronavirus coronavirus disease correlated COVID-19 Critical demonstrated develop disease disease severity greater healthy control hospitalized patient IgG response immune complex immune complex Immunoglobulin Immunoglobulin G implicated mechanism moderate modify outcome overactivation Pathogenesis Patient patients with COVID-19 plasma response responsible RNA SARS-CoV-2 severe COVID-19 severe patients severity systemically therapeutic strategy with COVID-19 [DOI] 10.1093/infdis/jiac091 PMC 바로가기
CD4 + T cells from COVID-19 mRNA vaccine recipients recognize a conserved epitope present in diverse coronavirusesClinical Trial Published on 2022-03-012022-10-04 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 임상, [키워드] Adaptive immunity assays bat coronavirus bat coronaviruses BNT162b2 CD4 common cold Coronaviruses conserved coronavirus coronavirus Coronaviruses COVID-19 COVID-19 vaccines demonstrated elicit Endemic epitope homologous Hypothesis induce majority MERS-CoV Moderna mRNA vaccine mRNA-1273 Outbreaks Pandemics participant peptide Pfizer-BioNTech recent recipient recognize Responder SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein Sequencing shown Support T cell T cell receptor T cell response vaccinated individual Vaccine zoonotic [DOI] 10.1172/JCI156083 PMC 바로가기 [Article Type] Clinical Trial
Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals전염병 및 COVID-19 회복기 개인의 교차 반응성 및 단일 반응성 SARS-CoV-2 CD4+ T 세포Research Article Published on 2021-12-292022-09-10 Journal: PLoS Pathogens [Category] SARS, 치료기술, 치료법, [키워드] Activation allele Amino acid amino acid sequence Amino acid sequences analysis assays Author CD4+ T cell class common cold common cold coronavirus common cold Coronaviruses common cold virus common cold viruses contributed convalescent convalescent individual convalescent individuals coronavirus coronavirus COVID-19 cross-react cross-reactive cross-reactivity defined demonstrated Direct dominant epitope DPB1 elicit elicited Endemic epitope Epitopes Ex vivo frequencies Frequency functional HLA-DP HLA-DR identify immunodominant low frequency marker membrane MHC-II naïve individuals nucleocapsid Nucleocapsid proteins overlapping PBMC peptide peptides Potential prevalent Previous studies previous study proportion protective immunity Protein reactive reagent recognizing SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-CoV-2 epitope SARS-CoV-2 epitopes sequence identity shown spike staining stratified subjects suggested T cell T cell epitope T cell epitopes T cell response T cell responses T cells the Spike to define unlikely viruses was used were used world population [DOI] 10.1371/journal.ppat.1010203 PMC 바로가기 [Article Type] Research Article
mRNA COVID-19 Vaccines and Long-Lived Plasma Cells: A Complicated RelationshipReview Published on 2021-12-202022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adjuvant administration all subjects article caused cellular common cold Coronaviruses COVID-19 COVID-19 vaccines cross-reactive demonstrated determine Evidence explain humoral immune response immune memory after COVID-19 disease immune memory after COVID-19 vaccination immunological mechanism Immunological memory induce late phase long-lived plasma cell long-lived plasma cells after mRNA COVID-19 vaccines memory memory B cell molecular mRNA mRNA COVID-19 vaccine mRNA COVID-19 vaccines mRNA vaccine naïve pandemic produced Protective Protein relationship SARS-CoV-2 SARS-CoV-2 mRNA vaccines SARS-CoV-2 virus subject the Spike vaccination Vaccine waning immunity [DOI] 10.3390/vaccines9121503 PMC 바로가기 [Article Type] Review
Deconvoluting the T Cell Response to SARS-CoV-2: Specificity Versus Chance and Cognate Cross-ReactivitySARS-CoV-2에 대한 T 세포 반응의 해체: 특이성 대 우연 및 동족 교차 반응성Immunology Published on 2021-05-282022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] Antibody Response Antigen antigens Biomarker chance characteristic clinically Cognate Cold common common cold common cold Coronaviruses coronavirus Course COVID-19 cross-reactive cross-reactivity ELISPOT exposure to False negative Human Immune monitoring immune protection Immunological memory ImmunoSpot individual individuals induce infected individual infected individuals infected with SARS-CoV-2 majority mega peptide pools Mild MOST negative control negative controls peptide peptide pool peptide pools provided respond response SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 antigens SARS-COV-2 infection serum antibodies serum antibody specific serum T cell T cell affinity T cell memory T cell response T cells Viral viral infections virus [DOI] 10.3389/fimmu.2021.635942 PMC 바로가기 [Article Type] Immunology
From Multiplex Serology to Serolomics—A Novel Approach to the Antibody Response against the SARS-CoV-2 Proteome다중 혈청학에서 혈청학으로 - SARS-CoV-2 단백질체에 대한 항체 반응에 대한 새로운 접근Article Published on 2021-04-242022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] age Algorithm analysis Antibody Response Antibody responses assays ccCoVs Cohort common cold common cold Coronaviruses Control Course COVID-19 case COVID-19 patient determine Disease progression dual E. coli ELISA enzyme-linked immunosorbent expressed fluorescent HEK293 cells hospitalized patient Ig isotype Ig isotypes immunofluorescence Immunoglobulin multiplex serology novel pathogen Pathogens Protein proteome Receptor-binding domain Research question response SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 N SARS-CoV-2 pandemic SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 research sensitivity Sensitivity and specificity Serological assay serological assays specificity Spike protein symptom onset the receptor-binding domain the SARS-CoV-2 the spike protein [DOI] 10.3390/v13050749 PMC 바로가기 [Article Type] Article
The Case for S2: The Potential Benefits of the S2 Subunit of the SARS-CoV-2 Spike Protein as an Immunogen in Fighting the COVID-19 PandemicS2의 경우: COVID-19 팬데믹과 싸우는 면역원으로서 SARS-CoV-2 스파이크 단백질의 S2 서브유닛의 잠재적 이점Immunology Published on 2021-03-092022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] Accessibility Affect antibodies antibody Antibody-dependent enhancement Antigen antigen competition B-cells benefit common cold common cold Coronaviruses conserved coronavirus COVID-19 COVID-19 case COVID-19 cases cross-reactive Evidence exposure to Fighting glycan glycans highlight HIV-1 Immunity immunogen imperative include memory memory B-cell neutralization neutralizing antibody Perspective Population Potential potential benefit potential benefits produced Receptor-binding domain Research S2 subunit SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 mutants SARS-CoV-2 vaccine similarities spike Spike protein Spike proteins stability steric T-cell T-cell responses T-cells target the receptor-binding domain the SARS-CoV-2 the spike protein therapy Vaccine Vaccine design Vaccines virus while [DOI] 10.3389/fimmu.2021.637651 PMC 바로가기 [Article Type] Immunology
Endemic SARS-CoV-2 will maintain post-pandemic immunity풍토병 SARS-CoV-2는 전염병 후 면역을 유지합니다Article Published on 2021-03-012022-09-12 Journal: Nature reviews. Immunology [Category] Fulltext, SARS, 진단, [키워드] common cold Coronaviruses COVID-19 Endemic Immunity immunological knowledge maintain pandemic population immunity SARS-CoV-2 vaccination [DOI] 10.1038/s41577-020-00493-9 PMC 바로가기 [Article Type] Article